MolNFT v1 · #76059 · protein
Crystal structure of the NTF2 domain of RAS GTPase-activating protein- binding protein 1
3Q90 · RAS GTPase-activating protein-binding protein 1: “Crystal structure of the NTF2 domain of RAS GTPase-activating protein- binding protein 1”. X-ray diffraction, 2 pockets (best druggability 0.49). MolNFT v1 #76059 on GenesisL1: 3D…
- PDB
- 3Q90
- Type
- protein
- Length
- 251 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RAS GTPase-activating protein-binding protein 1
- EC
- 3.6.4.12, 3.6.4.13
- UniProt
- Q13283
- Pockets
- 2 · best druggability 0.49
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RAS GTPase-activating protein-binding protein 1 (EC 3.6.4.12, 3.6.4.13) | protein | 121 | 35% helix, 42% strand | Q13283 |
| B | RAS GTPase-activating protein-binding protein 1 (EC 3.6.4.12, 3.6.4.13) | protein | 130 | 29% helix, 39% strand | Q13283 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 149 | 0.49 | 0.78 | 22 | empty |
| 2 | 60 | 0.35 | 0.77 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1379 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 3Q90 · Crystal structure of the NTF2 domain of Ras GTPase-activating protein-binding protein 1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q13283 · AlphaFold monomer V2.0 prediction for RAS GTPase-activating protein- binding protein 1… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13283
- Elsewhere: RCSB PDB 3Q90 · PDBe 3Q90 · UniProt Q13283
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