MolNFT v1 · #75851 · protein
Reduced sweetness of a monellin (mnei) mutant results from increased protein flexibility and disruption of a distant poly-(L-proline) II helix
3Q2P · Monellin chain B/MONELLIN chain a chimeric protein: “Reduced sweetness of a monellin (mnei) mutant results from increased protein flexibility and disruption of a…”. X-ray diffraction, 1 ligand (NA), 4 pockets (best druggability…
- PDB
- 3Q2P
- Type
- protein
- Length
- 385 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Monellin chain B/MONELLIN chain a chimeric protein
- UniProt
- P02882, P02881
- Ligands
- NA
- Pockets
- 4 · best druggability 0.59
Structure
x-ray diffraction · 2 distinct chains · 18% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, D | Monellin chain B/MONELLIN chain a chimeric protein | protein | 96 | 18% helix, 50% strand | P02882, P02881 |
| B | Monellin chain B/MONELLIN chain a chimeric protein | protein | 97 | 18% helix, 51% strand | P02882, P02881 |
Ligands and binding sites
- NA · Sodium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 182 | 0.59 | 0.82 | 23 | empty |
| 2 | 135 | 0.58 | 0.84 | 23 | empty |
| 3 | 246 | 0.48 | 0.74 | 32 | empty |
| 4 | 52 | 0.28 | 0.75 | 16 | empty |
Interfaces
4 interfaces between chains.
- C–D · 628 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 582 Ų buried · 5 hydrogen bonds · protein-protein
- B–D · 129 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 60 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3Q2P · Reduced sweetness of a monellin (MNEI) mutant results from increased protein flexibility… · the same entry in another collection · chain D against D, TM-score 1.00
- P02882 · AlphaFold monomer V2.0 prediction for monellin chain B (P02882) · a predicted model of the same protein · chain A against A, TM-score 0.49
- P02881 · AlphaFold monomer V2.0 prediction for monellin chain a (P02881) · a predicted model of the same protein · chain B against A, TM-score 0.45
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02882
- Every structure of UniProt P02881
- Elsewhere: RCSB PDB 3Q2P · PDBe 3Q2P · UniProt P02882 · UniProt P02881
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.