MolNFT v1 · #75833 · protein
Cyrstal structure of human alpha-synuclein (32-57) fused to maltose binding protein (mbp)
3Q27 · Maltose-binding periplasmic PROTEIN/ALPHA-synuclein…: “Cyrstal structure of human alpha-synuclein (32-57) fused to maltose binding protein (mbp)”. X-ray diffraction, 2 ligands (GLC, SO4), 3 pockets (best druggability 0.73). MolNFT…
- PDB
- 3Q27
- Type
- protein
- Length
- 390 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Maltose-binding periplasmic PROTEIN/ALPHA-synuclein chimeric protein
- UniProt
- P0AEX9, P37840
- Ligands
- GLC, SO4
- Pockets
- 3 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Maltose-binding periplasmic PROTEIN/ALPHA-synuclein chimeric protein | protein | 390 | 43% helix, 19% strand | P0AEX9, P37840 |
Ligands and binding sites
- GLC · alpha-D-glucopyranose · sugar · 2 copies · chains A
- SO4 · Sulfate ion · ion · 3 copies · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 234 | 0.73 | 0.87 | 29 | GLC, SO4 |
| 2 | 197 | 0.50 | 0.76 | 29 | empty |
| 3 | 119 | 0.38 | 0.74 | 20 | empty |
Compared structures
- 3Q27 · Cyrstal structure of human alpha-synuclein (32-57) fused to maltose binding protein (MBP) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AEX9
- Every structure of UniProt P37840
- Elsewhere: RCSB PDB 3Q27 · PDBe 3Q27 · UniProt P0AEX9 · UniProt P37840
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