MolNFT v1 · #75509 · protein
Structure of a viral otu domain protease bound to interferon- stimulated gene 15 (ISG15)
3PSE · RNA polymerase: “Structure of a viral otu domain protease bound to interferon- stimulated gene 15 (ISG15)”. X-ray diffraction, 1 ligand (3CN), 2 pockets (best druggability 0.41). MolNFT v1 #75509 on GenesisL1: 3D structure, binding…
- PDB
- 3PSE
- Type
- protein
- Length
- 314 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA polymerase; Ubiquitin-like protein ISG15
- UniProt
- Q6TQF5, P05161
- Ligands
- 3CN
- Pockets
- 2 · best druggability 0.41
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA polymerase | protein | 164 | 37% helix, 25% strand | Q6TQF5 |
| B | Ubiquitin-like protein ISG15 | protein | 150 | 25% helix, 33% strand | P05161 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 54 | 0.41 | 0.82 | 14 | empty |
| 2 | 118 | 0.39 | 0.75 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 1033 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 covalent (covalent ligand).
Compared structures
- 3PSE · Structure of a viral OTU domain protease bound to interferon-stimulated gene 15 (ISG15) · the same entry in another collection · chain A against A, TM-score 1.00
- P05161 · AlphaFold monomer V2.0 prediction for ubiquitin-like protein ISG15 (P05161) · a predicted model of the same protein · chain B against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6TQF5
- Every structure of UniProt P05161
- Elsewhere: RCSB PDB 3PSE · PDBe 3PSE · UniProt Q6TQF5 · UniProt P05161
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