MolNFT v1 · #75500 · protein
Crystal structure of the full-length human protein tyrosine phosphatase shp-1
3PS5 · Tyrosine-protein phosphatase non-receptor type 6: “Crystal structure of the full-length human protein tyrosine phosphatase shp-1”. X-ray diffraction, 1 ligand (SO4), 6 pockets (best druggability 0.63). MolNFT v1 #75500 on GenesisL1…
- PDB
- 3PS5
- Type
- protein
- Length
- 529 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein phosphatase non-receptor type 6
- EC
- 3.1.3.48
- UniProt
- P29350
- Ligands
- SO4
- Pockets
- 6 · best druggability 0.63
Structure
x-ray diffraction · 1 distinct chain · 29% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) | protein | 529 | 29% helix, 24% strand | P29350 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 5 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 274 | 0.63 | 0.81 | 32 | empty |
| 2 | 240 | 0.50 | 0.75 | 31 | empty |
| 3 | 148 | 0.46 | 0.76 | 21 | SO4 |
| 4 | 94 | 0.42 | 0.78 | 17 | empty |
| 5 | 142 | 0.41 | 0.74 | 25 | empty |
Compared structures
- 3PS5 · Crystal structure of the full-length Human Protein Tyrosine Phosphatase SHP-1 · the same entry in another collection · chain A against A, TM-score 1.00
- P29350 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 6… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P29350
- Elsewhere: RCSB PDB 3PS5 · PDBe 3PS5 · UniProt P29350
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