Ligand-binding domain of GLUA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 21% strand (DSSP).

Ligands and binding sites

• GLU · Glutamic acid · ligand · chains A
• G69 · N-[(2S)-5-{[4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2,3-dihydro-1H-inden-2-yl]propane-2-sulfonami de · ligand · chains A
• SO4 · Sulfate ion · ion · 7 copies · chains A
• GOL · Glycerol · additive · 2 copies · chains A
• DMS · Dimethyl sulfoxide · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

• 3PMW · Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an… · the same entry in another collection · chain A against A, TM-score 1.00
• P19491 · AlphaFold monomer V2.0 prediction for glutamate receptor 2 (P19491) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P19491
• Elsewhere: RCSB PDB 3PMW · PDBe 3PMW · UniProt P19491