MolNFT v1 · #75285 · protein
Crystal structure of PKA type I regulatory subunit bound with rp-8-br- camps
3PLQ · Camp-dependent protein kinase type I-alpha regulatory…: “Crystal structure of PKA type I regulatory subunit bound with rp-8-br- camps”. X-ray diffraction, 2 ligands (RP2, ZN), 1 pocket (best druggability 0.40). MolNFT v1 #75285 on…
- PDB
- 3PLQ
- Type
- protein
- Length
- 126 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Camp-dependent protein kinase type I-alpha regulatory subunit
- UniProt
- P00514
- Ligands
- RP2, ZN
- Pockets
- 1 · best druggability 0.40
Structure
x-ray diffraction · 1 distinct chain · 32% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Camp-dependent protein kinase type I-alpha regulatory subunit | protein | 126 | 32% helix, 31% strand | P00514 |
Ligands and binding sites
- RP2 · (2R,4aR,6R,7R,7aS)-6-(6-amino-8-bromo-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-sulfide · ligand · chains A
- ZN · Zinc ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 64 | 0.40 | 0.80 | 17 | RP2 |
Compared structures
- 3PLQ · Crystal structure of PKA type I regulatory subunit bound with Rp-8-Br-cAMPS · the same entry in another collection · chain A against A, TM-score 1.00
- P00514 · AlphaFold monomer V2.0 prediction for camp-dependent protein kinase type I-alpha… · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00514
- Elsewhere: RCSB PDB 3PLQ · PDBe 3PLQ · UniProt P00514
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