MolNFT v1 · #7522 · protein
Crystal structure of the bovine catalytic domain of alpha-1,3- galactosyltransferase in the presence of udp-galactose
1G93 · N-acetyllactosaminide alpha-1,3-galactosyltransferase: “Crystal structure of the bovine catalytic domain of alpha-1,3- galactosyltransferase in the presence of…”. X-ray diffraction, 4 ligands (UPG, GAL, MN), 3 pockets (best…
- PDB
- 1G93
- Type
- protein
- Length
- 277 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- N-acetyllactosaminide alpha-1,3-galactosyltransferase
- EC
- 2.4.1.151
- UniProt
- P14769
- Ligands
- UPG, GAL, MN, HG
- Pockets
- 3 · best druggability 0.61
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | N-acetyllactosaminide alpha-1,3-galactosyltransferase (EC 2.4.1.151) | protein | 277 | 37% helix, 20% strand | P14769 |
Ligands and binding sites
- UPG · Uridine-5'-diphosphate-glucose · ligand · chains A
- GAL · beta-D-galactopyranose · sugar · chains A
- MN · Manganese (II) ion · metal · chains A
- HG · Mercury (II) ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 266 | 0.61 | 0.80 | 25 | GAL, MN, HG, UPG |
| 2 | 92 | 0.39 | 0.76 | 16 | empty |
| 3 | 57 | 0.37 | 0.79 | 16 | empty |
Modifications
Observed in the structure: 1 glycan (glycosylation).
Compared structures
- 1G93 · Crystal structure of the bovine catalytic domain of alpha-1,3-galactosyltransferase in… · the same entry in another collection · chain A against A, TM-score 1.00
- P14769 · AlphaFold monomer V2.0 prediction for N-acetyllactosaminide… · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14769
- Elsewhere: RCSB PDB 1G93 · PDBe 1G93 · UniProt P14769
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