MolNFT v1 · #74999 · protein
Crystal structure of the sixth brct domain of human TOPBP1
3PD7 · DNA topoisomerase 2-binding protein 1: “Crystal structure of the sixth brct domain of human TOPBP1”. X-ray diffraction, 1 pocket (best druggability 0.35). MolNFT v1 #74999 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 3PD7
- Type
- protein
- Length
- 188 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA topoisomerase 2-binding protein 1
- UniProt
- Q92547
- Pockets
- 1 · best druggability 0.35
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | DNA topoisomerase 2-binding protein 1 | protein | 94 | 39% helix, 14% strand | Q92547 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 78 | 0.35 | 0.76 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 547 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 3PD7 · Crystal Structure of the Sixth BRCT Domain of Human TopBP1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q92547 · AlphaFold monomer V2.0 prediction for DNA topoisomerase 2-binding protein 1 (Q92547) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92547
- Elsewhere: RCSB PDB 3PD7 · PDBe 3PD7 · UniProt Q92547
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