MolNFT v1 · #74890 · protein

Crystal structure of uroporphyrinogen-III synthetase from helicobacter pylori 26695

3P9Z · Uroporphyrinogen III cosynthase (hemd): “Crystal structure of uroporphyrinogen-III synthetase from helicobacter pylori 26695”. X-ray diffraction, 1 pocket (best druggability 0.53). MolNFT v1 #74890 on GenesisL1: 3D structure…

PDB: 3P9Z
Type: protein
Length: 213 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Uroporphyrinogen III cosynthase (hemd)
UniProt: O25822
Pockets: 1 · best druggability 0.53

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Uroporphyrinogen III cosynthase (hemd)	protein	213	34% helix, 23% strand	O25822

Ligands and binding sites

MLI · Malonate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	315	0.53	0.74	38	MLI

Modifications

Observed in the structure: 3 modified (engineered).

Compared structures

3P9Z · Crystal structure of uroporphyrinogen-III synthetase from Helicobacter pylori 26695 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O25822
Elsewhere: RCSB PDB 3P9Z · PDBe 3P9Z · UniProt O25822

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