MolNFT v1 · #74363 · protein
PHD2-R717 with 40787422
3OUI · Egl nine homolog 1: “PHD2-R717 with 40787422”. X-ray diffraction, 2 ligands (42Z, FE2), 2 pockets (best druggability 0.67). MolNFT v1 #74363 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3OUI
- Type
- protein
- Length
- 190 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Egl nine homolog 1
- EC
- 1.14.11.-
- UniProt
- Q9GZT9
- Ligands
- 42Z, FE2
- Pockets
- 2 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 28% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Egl nine homolog 1 (EC 1.14.11.-) | protein | 190 | 28% helix, 34% strand | Q9GZT9 |
Ligands and binding sites
- 42Z · N-[(5,6-dichloro-1H-benzimidazol-2-yl)carbonyl]glycine · ligand · 2 copies · chains A
- FE2 · Fe (II) ion · metal · chains A
- ACT · Acetate ion · additive · 2 copies · chains A
- PEG · Di(hydroxyethyl)ether · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 102 | 0.67 | 0.90 | 19 | FE2, 42Z |
| 2 | 93 | 0.58 | 0.86 | 15 | 42Z |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9GZT9
- Elsewhere: RCSB PDB 3OUI · PDBe 3OUI · UniProt Q9GZT9
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