MolNFT v1 · #74346 · protein
Re-refined 3CS0
3OU0 · Periplasmic serine endoprotease degp: “Re-refined 3CS0”. X-ray diffraction, 7 pockets (best druggability 0.64). MolNFT v1 #74346 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3OU0
- Type
- protein
- Length
- 404 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Periplasmic serine endoprotease degp; Pentapeptide; Heptapeptide
- EC
- 3.4.21.-
- UniProt
- P0C0V0
- Pockets
- 7 · best druggability 0.64
Structure
x-ray diffraction · 3 distinct chains · 16% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Periplasmic serine endoprotease degp (EC 3.4.21.-) | protein | 392 | 17% helix, 41% strand | P0C0V0 |
| B | Pentapeptide | protein | 5 | 0% helix, 60% strand | — |
| C | Heptapeptide | protein | 7 | 0% helix, 29% strand | — |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 227 | 0.64 | 0.83 | 29 | empty |
| 2 | 178 | 0.54 | 0.79 | 24 | empty |
| 3 | 79 | 0.43 | 0.80 | 22 | empty |
| 4 | 106 | 0.42 | 0.78 | 27 | empty |
| 5 | 93 | 0.34 | 0.74 | 18 | empty |
Interfaces
2 interfaces between chains.
- A–C · 383 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 331 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 13 modified (engineered).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0C0V0
- Elsewhere: RCSB PDB 3OU0 · PDBe 3OU0 · UniProt P0C0V0
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