MolNFT v1 · #74104 · protein

Crystal structure of SSU72, an essential eukaryotic phosphatase specific for the C-terminal domain of RNA polymerase II

3OMW · CG14216: “Crystal structure of SSU72, an essential eukaryotic phosphatase specific for the C-terminal domain of RNA…”. X-ray diffraction, 8 pockets (best druggability 0.79). MolNFT v1 #74104 on GenesisL1: 3D structure, binding sites…

PDB: 3OMW
Type: protein
Length: 760 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CG14216
UniProt: Q9VWE4
Pockets: 8 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	CG14216	protein	190	45% helix, 18% strand	Q9VWE4

Pockets

8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	958	0.79	0.81	96	empty
2	304	0.61	0.79	32	empty
3	72	0.47	0.83	16	empty
4	129	0.45	0.77	26	empty
5	56	0.40	0.81	13	empty

Interfaces

5 interfaces between chains.

A–B · 612 Å² buried · 6 hydrogen bonds · protein-protein
A–D · 378 Å² buried · 12 hydrogen bonds · protein-protein
B–C · 358 Å² buried · 0 hydrogen bonds · protein-protein
A–C · 339 Å² buried · 3 hydrogen bonds · protein-protein
B–D · 35 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

3OMW · Crystal structure of Ssu72, an essential eukaryotic phosphatase specific for the… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9VWE4
Elsewhere: RCSB PDB 3OMW · PDBe 3OMW · UniProt Q9VWE4

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