Research workbench
Crystal structure of SSU72, an essential eukaryotic phosphatase specific for the C-terminal domain of RNA polymerase II
Analyse Crystal structure of SSU72, an essential eukaryotic phosphatase specific for… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3OMW
- Type
- protein
- Length
- 760 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CG14216
- UniProt
- Q9VWE4
- Pockets
- 8 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 45% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | CG14216 | protein | 190 | 45% helix, 18% strand | Q9VWE4 |
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 958 | 0.79 | 0.81 | 96 | empty |
| 2 | 304 | 0.61 | 0.79 | 32 | empty |
| 3 | 72 | 0.47 | 0.83 | 16 | empty |
| 4 | 129 | 0.45 | 0.77 | 26 | empty |
| 5 | 56 | 0.40 | 0.81 | 13 | empty |
Interfaces
5 interfaces between chains.
- A–B · 612 Ų buried · 6 hydrogen bonds · protein-protein
- A–D · 378 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 358 Ų buried · 0 hydrogen bonds · protein-protein
- A–C · 339 Ų buried · 3 hydrogen bonds · protein-protein
- B–D · 35 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3OMW · Crystal structure of Ssu72, an essential eukaryotic phosphatase specific for the… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9VWE4
- Elsewhere: RCSB PDB 3OMW · PDBe 3OMW · UniProt Q9VWE4
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