MolNFT v1 · #74057 · protein
Crystal structure of human ribonucleotide reductase subunit M2 (HRRM2)
3OLJ · Ribonucleoside-diphosphate reductase subunit M2: “Crystal structure of human ribonucleotide reductase subunit M2 (HRRM2)”. X-ray diffraction, 1 ligand (NA), 16 pockets (best druggability 0.77). MolNFT v1 #74057 on GenesisL1: 3D…
- PDB
- 3OLJ
- Type
- protein
- Length
- 1,144 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ribonucleoside-diphosphate reductase subunit M2
- EC
- 1.17.4.1
- UniProt
- P31350
- Ligands
- NA
- Pockets
- 16 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 72% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) | protein | 286 | 72% helix, 0% strand | P31350 |
Ligands and binding sites
- NA · Sodium ion · metal · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
16 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 96 | 0.77 | 0.98 | 38 | empty |
| 2 | 72 | 0.72 | 0.97 | 30 | empty |
| 3 | 544 | 0.64 | 0.76 | 65 | empty |
| 4 | 438 | 0.62 | 0.76 | 59 | empty |
| 5 | 158 | 0.54 | 0.80 | 25 | empty |
Interfaces
4 interfaces between chains.
- A–D · 1611 Ų buried · 17 hydrogen bonds · protein-protein
- B–C · 1590 Ų buried · 17 hydrogen bonds · protein-protein
- B–D · 235 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 221 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 3OLJ · Crystal structure of human ribonucleotide reductase subunit M2 (hRRM2) · the same entry in another collection · chain A against A, TM-score 1.00
- P31350 · AlphaFold monomer V2.0 prediction for ribonucleoside-diphosphate reductase subunit M2… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P31350
- Elsewhere: RCSB PDB 3OLJ · PDBe 3OLJ · UniProt P31350
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