MolNFT v1 · #74050 · protein
Crystal structure of the N-terminal region of TOPBP1
3OLC · DNA topoisomerase 2-binding protein 1: “Crystal structure of the N-terminal region of TOPBP1”. X-ray diffraction, 2 pockets (best druggability 0.40). MolNFT v1 #74050 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3OLC
- Type
- protein
- Length
- 280 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA topoisomerase 2-binding protein 1
- UniProt
- Q92547
- Pockets
- 2 · best druggability 0.40
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| X | DNA topoisomerase 2-binding protein 1 | protein | 280 | 40% helix, 16% strand | Q92547 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 89 | 0.40 | 0.78 | 15 | empty |
| 2 | 60 | 0.33 | 0.77 | 17 | empty |
Modifications
Observed in the structure: 8 modified (engineered).
Compared structures
- 3OLC · Crystal structure of the N-terminal region of TopBP1 · the same entry in another collection · chain X against X, TM-score 1.00
- Q92547 · AlphaFold monomer V2.0 prediction for DNA topoisomerase 2-binding protein 1 (Q92547) · a predicted model of the same protein · chain X against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92547
- Elsewhere: RCSB PDB 3OLC · PDBe 3OLC · UniProt Q92547
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