MolNFT v1 · #73804 · protein
Crystal structure of P38ALPHA Y323T active mutant
3OD6 · Mitogen-activated protein kinase 14: “Crystal structure of P38ALPHA Y323T active mutant”. X-ray diffraction, 5 pockets (best druggability 0.68). MolNFT v1 #73804 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3OD6
- Type
- protein
- Length
- 344 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitogen-activated protein kinase 14
- EC
- 2.7.11.24
- UniProt
- Q16539
- Pockets
- 5 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| X | Mitogen-activated protein kinase 14 (EC 2.7.11.24) | protein | 344 | 39% helix, 15% strand | Q16539 |
Ligands and binding sites
- BOG · octyl beta-D-glucopyranoside · additive · chains X
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 187 | 0.68 | 0.86 | 27 | BOG |
| 2 | 390 | 0.65 | 0.79 | 39 | empty |
| 3 | 163 | 0.46 | 0.76 | 20 | empty |
| 4 | 133 | 0.41 | 0.75 | 29 | empty |
| 5 | 57 | 0.28 | 0.74 | 16 | empty |
Compared structures
- 3OD6 · Crystal structure of p38alpha Y323T active mutant · the same entry in another collection · chain X against X, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q16539
- Elsewhere: RCSB PDB 3OD6 · PDBe 3OD6 · UniProt Q16539
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