MolNFT v1 · #7333 · protein
Crystal structure of the XTCF3-CBD/BETA-catenin armadillo repeat complex
1G3J · Beta-catenin armadillo repeat region: “Crystal structure of the XTCF3-CBD/BETA-catenin armadillo repeat complex”. X-ray diffraction, 7 pockets (best druggability 0.56). MolNFT v1 #7333 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1G3J
- Type
- protein
- Length
- 1,036 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta-catenin armadillo repeat region; TCF3-cbd (catenin binding domain)
- UniProt
- P35222, P70062
- Pockets
- 7 · best druggability 0.56
Structure
x-ray diffraction · 4 distinct chains · 71% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Beta-catenin armadillo repeat region | protein | 522 | 76% helix, 0% strand | P35222 |
| B | TCF3-cbd (catenin binding domain) | protein | 41 | 20% helix, 10% strand | P70062 |
| C | Beta-catenin armadillo repeat region | protein | 439 | 74% helix, 0% strand | P35222 |
| D | TCF3-cbd (catenin binding domain) | protein | 34 | 24% helix, 12% strand | P70062 |
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 336 | 0.56 | 0.75 | 25 | empty |
| 2 | 118 | 0.46 | 0.78 | 23 | empty |
| 3 | 166 | 0.42 | 0.74 | 24 | empty |
| 4 | 78 | 0.40 | 0.79 | 23 | empty |
| 5 | 111 | 0.38 | 0.74 | 23 | empty |
Interfaces
4 interfaces between chains.
- A–B · 2312 Ų buried · 39 hydrogen bonds · protein-protein
- C–D · 1796 Ų buried · 31 hydrogen bonds · protein-protein
- A–C · 517 Ų buried · 2 hydrogen bonds · protein-protein
- A–D · 84 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1G3J · Crystal structure of the XTCF3-CBD/BETA-catenin armadillo repeat complex · the same entry in another collection · chain D against D, TM-score 1.00
- P35222 · AlphaFold monomer V2.0 prediction for catenin beta-1 (P35222) · a predicted model of the same protein · chain C against A, TM-score 1.00
- P70062 · AlphaFold monomer V2.0 prediction for transcription factor 7-like 1-a (P70062) · a predicted model of the same protein · chain D against A, TM-score 0.32
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35222
- Every structure of UniProt P70062
- Elsewhere: RCSB PDB 1G3J · PDBe 1G3J · UniProt P35222 · UniProt P70062
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