MolNFT v1 · #72928 · protein

Complex of 6-hydroxy-L-nicotine oxidase with nicotinamide

3NN0: “Complex of 6-hydroxy-L-nicotine oxidase with nicotinamide”. X-ray diffraction, 3 ligands (NCA, FAD, GP7), 3 pockets (best druggability 0.85). MolNFT v1 #72928 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3NN0
Type: protein
Length: 425 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 6-hydroxy-L-nicotine oxidase
EC: 1.5.3.5
UniProt: Q93NH4
Ligands: NCA, FAD, GP7
Pockets: 3 · best druggability 0.85

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
X	6-hydroxy-L-nicotine oxidase (EC 1.5.3.5)	protein	425	34% helix, 23% strand	Q93NH4

Ligands and binding sites

NCA · Nicotinamide · ligand · chains X
FAD · Flavin-adenine dinucleotide · ligand · chains X
GP7 · (1R)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(pentadecanoyloxy)methyl]ethyl (12E)-hexadeca-9,12-dienoate · ligand · chains X

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	441	0.85	0.92	66	NCA, FAD
2	439	0.74	0.83	51	GP7
3	115	0.46	0.79	18	empty

Compared structures

3NN0 · Complex of 6-hydroxy-L-nicotine oxidase with nicotinamide · the same entry in another collection · chain X against X, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q93NH4
Elsewhere: RCSB PDB 3NN0 · PDBe 3NN0 · UniProt Q93NH4

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.