MolNFT v1 · #7260 · protein

Crystal structure of protein tyrosine phosphatase 1B complexed with a mono-phosphorylated peptide (ETDY(PTR)RKGGKGLL) from the insulin receptor kinase

1G1G: “Crystal structure of protein tyrosine phosphatase 1B complexed with a mono-phosphorylated peptide…”. X-ray diffraction, 1 pocket (best druggability 0.32). MolNFT v1 #7260 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1G1G
Type: protein
Length: 303 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein tyrosine phosphatase 1B; Mono-phosphorylated peptide from the insulin receptor…
EC: 3.1.3.48
UniProt: P18031
Pockets: 1 · best druggability 0.32

Structure

x-ray diffraction · 2 distinct chains · 37% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein tyrosine phosphatase 1B (EC 3.1.3.48)	protein	298	38% helix, 19% strand	P18031
B	Mono-phosphorylated peptide from the insulin receptor kinase	protein	5	0% helix, 0% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	68	0.32	0.75	18	empty

Interfaces

1 interface between chains.

A–B · 417 Å² buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

1G1G · Crystal structure of protein tyrosine phosphatase 1B complexed with a mono-phosphorylated… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P18031
Elsewhere: RCSB PDB 1G1G · PDBe 1G1G · UniProt P18031

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