MolNFT v1 · #72578 · protein + RNA
Structural and functional insights into pattern recognition by the innate immune receptor rig-I
3NCU: “Structural and functional insights into pattern recognition by the innate immune receptor rig-I”. X-ray diffraction, 1 ligand (ZN), 2 pockets (best druggability 0.67). MolNFT v1 #72578 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3NCU
- Type
- protein + RNA
- Length
- 264 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Rig-I; 5'-R(*(GDP)P*AP*CP*GP*CP*UP*AP*GP*CP*GP*UP*C)-3'
- EC
- 3.6.1.-
- UniProt
- O95786
- Ligands
- ZN
- Pockets
- 2 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 13% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Rig-I (EC 3.6.1.-) | protein | 120 | 13% helix, 50% strand | O95786 |
| C, D | 5'-R(*(GDP)P*AP*CP*GP*CP*UP*AP*GP*CP*GP*UP*C)-3' | rna | 12 | — | — |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 826 | 0.67 | 0.75 | 46 | empty |
| 2 | 55 | 0.33 | 0.77 | 15 | empty |
Interfaces
5 interfaces between chains.
- C–D · 555 Ų buried · 53 hydrogen bonds · nucleic-nucleic
- B–D · 431 Ų buried · 10 hydrogen bonds · protein-nucleic
- A–C · 420 Ų buried · 9 hydrogen bonds · protein-nucleic
- A–D · 179 Ų buried · 5 hydrogen bonds · protein-nucleic
- B–C · 168 Ų buried · 3 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 2 modified (nucleotide modification).
Compared structures
- 3NCU · Structural and functional insights into pattern recognition by the innate immune receptor… · the same entry in another collection · chain A against A, TM-score 1.00
- O95786 · AlphaFold monomer V2.0 prediction for antiviral innate immune response receptor rig-I… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95786
- Elsewhere: RCSB PDB 3NCU · PDBe 3NCU · UniProt O95786
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