MolNFT v1 · #71792 · protein
Crystal structures of two intensely sweet proteins
3MON · Monellin: “Crystal structures of two intensely sweet proteins”. X-ray diffraction, 3 pockets (best druggability 0.66). MolNFT v1 #71792 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3MON
- Type
- protein
- Length
- 376 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Monellin
- UniProt
- P02881, P02882
- Pockets
- 3 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 18% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E, G | Monellin | protein | 44 | 0% helix, 61% strand | P02881 |
| B, D, F, H | Monellin | protein | 50 | 34% helix, 32% strand | P02882 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 291 | 0.66 | 0.82 | 30 | empty |
| 2 | 287 | 0.59 | 0.78 | 33 | empty |
| 3 | 118 | 0.44 | 0.77 | 25 | empty |
Interfaces
15 interfaces between chains.
- G–H · 1321 Ų buried · 18 hydrogen bonds · protein-protein
- A–B · 1317 Ų buried · 19 hydrogen bonds · protein-protein
- E–F · 1285 Ų buried · 18 hydrogen bonds · protein-protein
- C–D · 1269 Ų buried · 12 hydrogen bonds · protein-protein
- F–H · 244 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3MON · Crystal structures of two intensely sweet proteins · the same entry in another collection · chain H against H, TM-score 1.00
- P02882 · AlphaFold monomer V2.0 prediction for monellin chain B (P02882) · a predicted model of the same protein · chain B against A, TM-score 0.88
- P02881 · AlphaFold monomer V2.0 prediction for monellin chain a (P02881) · a predicted model of the same protein · chain A against A, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02881
- Every structure of UniProt P02882
- Elsewhere: RCSB PDB 3MON · PDBe 3MON · UniProt P02881 · UniProt P02882
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