MolNFT v1 · #71556 · protein
Fnr-recruitment to the thylakoid
3MHP · Ferredoxin--NADP reductase, leaf isozyme, chloroplastic: “Fnr-recruitment to the thylakoid”. X-ray diffraction, 1 ligand (FAD), 6 pockets (best druggability 0.62). MolNFT v1 #71556 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3MHP
- Type
- protein
- Length
- 611 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ferredoxin--NADP reductase, leaf isozyme, chloroplastic; TIC62_PEPTIDE
- EC
- 1.18.1.2
- UniProt
- P10933, Q8SKU2
- Ligands
- FAD
- Pockets
- 6 · best druggability 0.62
Structure
x-ray diffraction · 3 distinct chains · 25% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic (EC 1.18.1.2) | protein | 296 | 25% helix, 32% strand | P10933 |
| B | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic (EC 1.18.1.2) | protein | 289 | 27% helix, 30% strand | P10933 |
| C | TIC62_PEPTIDE | protein | 26 | 0% helix, 4% strand | Q8SKU2 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 328 | 0.62 | 0.79 | 51 | FAD |
| 2 | 381 | 0.60 | 0.77 | 47 | FAD |
| 3 | 197 | 0.48 | 0.76 | 29 | empty |
| 4 | 94 | 0.41 | 0.78 | 18 | empty |
| 5 | 156 | 0.40 | 0.73 | 39 | empty |
Interfaces
3 interfaces between chains.
- A–C · 957 Ų buried · 11 hydrogen bonds · protein-protein
- B–C · 856 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 410 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 3MHP · FNR-recruitment to the thylakoid · the same entry in another collection · chain A against A, TM-score 1.00
- P10933 · AlphaFold monomer V2.0 prediction for ferredoxin--NADP reductase, leaf isozyme… · a predicted model of the same protein · chain B against A, TM-score 0.99
- Q8SKU2 · AlphaFold monomer V2.0 prediction for protein tic 62, chloroplastic (Q8SKU2) · a predicted model of the same protein · chain C against A, TM-score 0.22
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10933
- Every structure of UniProt Q8SKU2
- Elsewhere: RCSB PDB 3MHP · PDBe 3MHP · UniProt P10933 · UniProt Q8SKU2
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