MolNFT v1 · #71372 · protein
Crystal structure of the nac domain of alpha subunit of nascent polypeptide-associated COMPLEX(NAC)
3MCE · Nascent polypeptide-associated complex subunit alpha: “Crystal structure of the nac domain of alpha subunit of nascent polypeptide-associated COMPLEX(NAC)”. X-ray diffraction, 1 ligand (IOD), 1 pocket (best druggability 0.74).…
- PDB
- 3MCE
- Type
- protein
- Length
- 233 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nascent polypeptide-associated complex subunit alpha
- UniProt
- Q13765
- Ligands
- IOD
- Pockets
- 1 · best druggability 0.74
Structure
x-ray diffraction · 4 distinct chains · 8% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nascent polypeptide-associated complex subunit alpha | protein | 57 | 5% helix, 49% strand | Q13765 |
| B | Nascent polypeptide-associated complex subunit alpha | protein | 60 | 10% helix, 50% strand | Q13765 |
| C | Nascent polypeptide-associated complex subunit alpha | protein | 59 | 10% helix, 49% strand | Q13765 |
| D | Nascent polypeptide-associated complex subunit alpha | protein | 57 | 7% helix, 60% strand | Q13765 |
Ligands and binding sites
- IOD · Iodide ion · ion · 8 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 58 | 0.74 | 0.98 | 19 | empty |
Interfaces
6 interfaces between chains.
- C–D · 1028 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 995 Ų buried · 21 hydrogen bonds · protein-protein
- A–C · 421 Ų buried · 1 hydrogen bond · protein-protein
- B–D · 355 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 351 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 3MCE · Crystal structure of the NAC domain of alpha subunit of nascent polypeptide-associated… · the same entry in another collection · chain D against D, TM-score 1.00
- Q13765 · AlphaFold monomer V2.0 prediction for nascent polypeptide-associated complex subunit… · a predicted model of the same protein · chain D against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13765
- Elsewhere: RCSB PDB 3MCE · PDBe 3MCE · UniProt Q13765
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