Crystal structure of the human BRDG1/STAP-1 SH2 domain in complex with the ntal PTYR136 peptide

Structure

x-ray diffraction · 2 distinct chains · 22% helix, 28% strand (DSSP).

Ligands and binding sites

• NH2 · Amino group · ion · chains A, B
• MLI · Malonate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 783 Ų buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

• 3MAZ · Crystal Structure of the Human BRDG1/STAP-1 SH2 Domain in Complex with the NTAL pTyr136… · the same entry in another collection · chain A against A, TM-score 1.00
• Q9ULZ2 · AlphaFold monomer V2.0 prediction for signal-transducing adaptor protein 1 (Q9ULZ2) · a predicted model of the same protein · chain A against A, TM-score 0.95
• Q9GZY6 · AlphaFold monomer V2.0 prediction for linker for activation of T-cells family member 2… · a predicted model of the same protein · chain B against A, TM-score 0.34

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9ULZ2
• Every structure of UniProt Q9GZY6
• Elsewhere: RCSB PDB 3MAZ · PDBe 3MAZ · UniProt Q9ULZ2 · UniProt Q9GZY6