MolNFT v1 · #71279 · protein

Electron crystallographic structure of lens aquaporin-0 (AQP0) (lens mip) in E. COLI polar lipids

3M9I · Lens fiber major intrinsic protein: “Electron crystallographic structure of lens aquaporin-0 (AQP0) (lens mip) in E. COLI polar lipids”. Electron crystallography, 1 ligand (3PE), 2 pockets (best druggability 0.42). MolNFT v1 #71279…

PDB: 3M9I
Type: protein
Length: 220 residues
Chains: 1
Method: electron crystallography
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lens fiber major intrinsic protein
UniProt: Q6J8I9
Ligands: 3PE
Pockets: 2 · best druggability 0.42

Structure

electron crystallography · 1 distinct chain · 67% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Lens fiber major intrinsic protein	protein	220	67% helix, 0% strand	Q6J8I9

Ligands and binding sites

3PE · 1,2-diacyl-sn-glycero-3-phosphoethanolamine · ligand · 7 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	111	0.42	0.77	22	empty
2	104	0.36	0.74	25	empty

Compared structures

3M9I · Electron crystallographic structure of lens Aquaporin-0 (AQP0) (lens MIP) in E. coli… · the same entry in another collection · chain A against A, TM-score 1.00
Q6J8I9 · AlphaFold monomer V2.0 prediction for lens fiber major intrinsic protein (Q6J8I9) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6J8I9
Elsewhere: RCSB PDB 3M9I · PDBe 3M9I · UniProt Q6J8I9

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