MolNFT v1 · #70969 · protein
Crystal structure of TRAF2:CIAP2 complex
3M0A · TNF receptor-associated factor 2: “Crystal structure of TRAF2:CIAP2 complex”. X-ray diffraction, 1 ligand (ZN), 1 pocket (best druggability 0.37). MolNFT v1 #70969 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3M0A
- Type
- protein
- Length
- 260 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TNF receptor-associated factor 2; Baculoviral iap repeat-containing protein 3
- UniProt
- Q12933, Q13489
- Ligands
- ZN
- Pockets
- 1 · best druggability 0.37
Structure
x-ray diffraction · 2 distinct chains · 63% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | TNF receptor-associated factor 2 | protein | 62 | 97% helix, 0% strand | Q12933 |
| D | Baculoviral iap repeat-containing protein 3 | protein | 74 | 34% helix, 16% strand | Q13489 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 121 | 0.37 | 0.74 | 19 | empty |
Interfaces
5 interfaces between chains.
- B–C · 1216 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 1148 Ų buried · 0 hydrogen bonds · protein-protein
- A–C · 1063 Ų buried · 3 hydrogen bonds · protein-protein
- C–D · 510 Ų buried · 9 hydrogen bonds · protein-protein
- B–D · 233 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 3M0A · Crystal structure of TRAF2:cIAP2 complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q13489 · AlphaFold monomer V2.0 prediction for baculoviral iap repeat- containing protein 3… · a predicted model of the same protein · chain D against A, TM-score 0.91
- Q12933 · AlphaFold monomer V2.0 prediction for TNF receptor-associated factor 2 (Q12933) · a predicted model of the same protein · chain A against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12933
- Every structure of UniProt Q13489
- Elsewhere: RCSB PDB 3M0A · PDBe 3M0A · UniProt Q12933 · UniProt Q13489
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