MolNFT v1 · #70956 · protein
Crystal structure of ferredoxin-NADP+ oxidoreductase from bacillus subtilis (form II)
3LZX · Ferredoxin--NADP reductase 2: “Crystal structure of ferredoxin-NADP+ oxidoreductase from bacillus subtilis (form II)”. X-ray diffraction, 3 ligands (FAD, NAP, NA), 5 pockets (best druggability 0.75). MolNFT v1 #70956 on GenesisL1…
- PDB
- 3LZX
- Type
- protein
- Length
- 658 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ferredoxin--NADP reductase 2
- EC
- 1.18.1.2
- UniProt
- O05268
- Ligands
- FAD, NAP, NA
- Pockets
- 5 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 26% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Ferredoxin--NADP reductase 2 (EC 1.18.1.2) | protein | 329 | 26% helix, 31% strand | O05268 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · 2 copies · chains A, B
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · 2 copies · chains A, B
- NA · Sodium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 253 | 0.75 | 0.88 | 53 | FAD |
| 2 | 375 | 0.73 | 0.84 | 65 | FAD |
| 3 | 67 | 0.65 | 0.93 | 18 | empty |
| 4 | 456 | 0.62 | 0.76 | 55 | NAP |
| 5 | 198 | 0.46 | 0.74 | 37 | NAP |
Interfaces
1 interface between chains.
- A–B · 1786 Ų buried · 31 hydrogen bonds · protein-protein
Compared structures
- 3LZX · Crystal structure of ferredoxin-NADP+ oxidoreductase from Bacillus subtilis (FORM II) · the same entry in another collection · chain A against A, TM-score 1.00
- O05268 · AlphaFold monomer V2.0 prediction for ferredoxin--NADP reductase 2 (O05268) · a predicted model of the same protein · chain B against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O05268
- Elsewhere: RCSB PDB 3LZX · PDBe 3LZX · UniProt O05268
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