MolNFT v1 · #70861 · protein

Crystal structure of putative DNA cytosine methylase from shigella flexneri 2A str. 2457T

3LX6 · Cytosine-specific methyltransferase: “Crystal structure of putative DNA cytosine methylase from shigella flexneri 2A str. 2457T”. X-ray diffraction, 10 pockets (best druggability 0.72). MolNFT v1 #70861 on GenesisL1: 3D structure…

PDB: 3LX6
Type: protein
Length: 730 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cytosine-specific methyltransferase
EC: 2.1.1.37
UniProt: E3Y0J2
Pockets: 10 · best druggability 0.72

Structure

x-ray diffraction · 2 distinct chains · 40% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cytosine-specific methyltransferase (EC 2.1.1.37)	protein	368	42% helix, 14% strand	E3Y0J2
B	Cytosine-specific methyltransferase (EC 2.1.1.37)	protein	362	39% helix, 13% strand	E3Y0J2

Pockets

10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	734	0.72	0.78	80	empty
2	166	0.64	0.85	29	empty
3	340	0.64	0.79	40	empty
4	255	0.59	0.79	38	empty
5	369	0.55	0.74	51	empty

Interfaces

1 interface between chains.

A–B · 970 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 12 modified (engineered).

Compared structures

3LX6 · Crystal structure of putative dna cytosine methylase from shigella flexneri 2a str. 2457T · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt E3Y0J2
Elsewhere: RCSB PDB 3LX6 · PDBe 3LX6 · UniProt E3Y0J2

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.