Research workbench
Crystal structure of putative DNA cytosine methylase from shigella flexneri 2A str. 2457T
Analyse Crystal structure of putative DNA cytosine methylase from shigella flexneri 2A… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3LX6
- Type
- protein
- Length
- 730 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cytosine-specific methyltransferase
- EC
- 2.1.1.37
- UniProt
- E3Y0J2
- Pockets
- 10 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cytosine-specific methyltransferase (EC 2.1.1.37) | protein | 368 | 42% helix, 14% strand | E3Y0J2 |
| B | Cytosine-specific methyltransferase (EC 2.1.1.37) | protein | 362 | 39% helix, 13% strand | E3Y0J2 |
Pockets
10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 734 | 0.72 | 0.78 | 80 | empty |
| 2 | 166 | 0.64 | 0.85 | 29 | empty |
| 3 | 340 | 0.64 | 0.79 | 40 | empty |
| 4 | 255 | 0.59 | 0.79 | 38 | empty |
| 5 | 369 | 0.55 | 0.74 | 51 | empty |
Interfaces
1 interface between chains.
- A–B · 970 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 modified (engineered).
Compared structures
- 3LX6 · Crystal structure of putative dna cytosine methylase from shigella flexneri 2a str. 2457T · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E3Y0J2
- Elsewhere: RCSB PDB 3LX6 · PDBe 3LX6 · UniProt E3Y0J2
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