MolNFT v1 · #70688 · protein
HPRP8 non-native subdomain
3LRU · Pre-mRNA-processing-splicing factor 8: “HPRP8 non-native subdomain”. X-ray diffraction, 4 pockets (best druggability 0.57). MolNFT v1 #70688 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3LRU
- Type
- protein
- Length
- 300 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pre-mRNA-processing-splicing factor 8
- UniProt
- Q6P2Q9
- Pockets
- 4 · best druggability 0.57
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pre-mRNA-processing-splicing factor 8 | protein | 160 | 37% helix, 21% strand | Q6P2Q9 |
| B | Pre-mRNA-processing-splicing factor 8 | protein | 140 | 41% helix, 18% strand | Q6P2Q9 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 302 | 0.57 | 0.77 | 44 | empty |
| 2 | 110 | 0.45 | 0.78 | 21 | empty |
| 3 | 54 | 0.34 | 0.78 | 16 | empty |
| 4 | 62 | 0.33 | 0.76 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 3301 Ų buried · 44 hydrogen bonds · protein-protein
Compared structures
- 3LRU · hPRP8 Non-Native Subdomain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6P2Q9
- Elsewhere: RCSB PDB 3LRU · PDBe 3LRU · UniProt Q6P2Q9
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