MolNFT v1 · #70406 · protein

Glucose-6-phosphate isomerase from francisella tularensis.

3LJK: “Glucose-6-phosphate isomerase from francisella tularensis.”. X-ray diffraction, 1 ligand (CA), 4 pockets (best druggability 0.65). MolNFT v1 #70406 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3LJK
Type: protein
Length: 543 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glucose-6-phosphate isomerase
EC: 5.3.1.9
UniProt: Q5NFC4
Ligands: CA
Pockets: 4 · best druggability 0.65

Structure

x-ray diffraction · 1 distinct chain · 55% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glucose-6-phosphate isomerase (EC 5.3.1.9)	protein	543	55% helix, 12% strand	Q5NFC4

Ligands and binding sites

CA · Calcium ion · metal · chains A
MES · 2-(N-morpholino)-ethanesulfonic acid · additive · chains A
GOL · Glycerol · additive · chains A
IPA · Isopropyl alcohol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	369	0.65	0.79	40	empty
2	58	0.50	0.86	17	empty
3	54	0.47	0.85	15	empty
4	66	0.31	0.75	15	empty

Modifications

Observed in the structure: 10 modified, 1 disulfide (engineered, disulfide).

Compared structures

3LJK · Glucose-6-phosphate isomerase from Francisella tularensis. · the same entry in another collection · chain A against A, TM-score 1.00
Q5NFC4 · AlphaFold monomer V2.0 prediction for glucose-6-phosphate isomerase (Q5NFC4) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5NFC4
Elsewhere: RCSB PDB 3LJK · PDBe 3LJK · UniProt Q5NFC4

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