MolNFT v1 · #70154 · protein
Crystal structure of the cytoplasmic tail of (PRO)RENIN receptor as a mbp fusion (maltose-free form)
3LC8 · Maltose-binding periplasmic protein, renin receptor: “Crystal structure of the cytoplasmic tail of (PRO)RENIN receptor as a mbp fusion (maltose-free form)”. X-ray diffraction, 1 ligand (MG), 8 pockets (best druggability 0.62).…
- PDB
- 3LC8
- Type
- protein
- Length
- 746 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Maltose-binding periplasmic protein, renin receptor
- UniProt
- P0AEX9, O75787
- Ligands
- MG
- Pockets
- 8 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 44% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Maltose-binding periplasmic protein, renin receptor | protein | 372 | 44% helix, 19% strand | P0AEX9, O75787 |
| B | Maltose-binding periplasmic protein, renin receptor | protein | 374 | 44% helix, 20% strand | P0AEX9, O75787 |
Ligands and binding sites
- MG · Magnesium ion · metal · chains A
- GOL · Glycerol · additive · 3 copies · chains A, B
- PG4 · Tetraethylene glycol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 422 | 0.62 | 0.76 | 51 | empty |
| 2 | 399 | 0.60 | 0.76 | 48 | empty |
| 3 | 85 | 0.46 | 0.81 | 21 | empty |
| 4 | 113 | 0.45 | 0.79 | 19 | empty |
| 5 | 97 | 0.43 | 0.79 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 899 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 3LC8 · Crystal structure of the cytoplasmic tail of (pro)renin receptor as a MBP fusion… · the same entry in another collection · chain A against A, TM-score 1.00
- O75787 · AlphaFold monomer V2.0 prediction for renin receptor (O75787) · a predicted model of the same protein · chain A against A, TM-score 0.24
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AEX9
- Every structure of UniProt O75787
- Elsewhere: RCSB PDB 3LC8 · PDBe 3LC8 · UniProt P0AEX9 · UniProt O75787
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