MolNFT v1 · #69942 · protein
Crystal structure of fniii domains of human GP130 (domains 4-6)
3L5J · Interleukin-6 receptor subunit beta: “Crystal structure of fniii domains of human GP130 (domains 4-6)”. X-ray diffraction, 1 ligand (CL), 3 pockets (best druggability 0.66). MolNFT v1 #69942 on GenesisL1: 3D structure, binding sites…
- PDB
- 3L5J
- Type
- protein
- Length
- 569 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interleukin-6 receptor subunit beta
- UniProt
- P40189
- Ligands
- CL
- Pockets
- 3 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 3% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interleukin-6 receptor subunit beta | protein | 283 | 3% helix, 50% strand | P40189 |
| B | Interleukin-6 receptor subunit beta | protein | 286 | 3% helix, 48% strand | P40189 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 577 | 0.66 | 0.76 | 49 | empty |
| 2 | 70 | 0.34 | 0.76 | 21 | empty |
| 3 | 50 | 0.29 | 0.75 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 262 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 3L5J · Crystal structure of FnIII domains of human GP130 (Domains 4-6) · the same entry in another collection · chain A against A, TM-score 1.00
- P40189 · AlphaFold monomer V2.0 prediction for interleukin-6 receptor subunit beta (P40189) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P40189
- Elsewhere: RCSB PDB 3L5J · PDBe 3L5J · UniProt P40189
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