MolNFT v1 · #6988 · protein
Crystal structure of the RNA-binding domain of the mRNA export factor tap
1FT8 · Tip associating protein: “Crystal structure of the RNA-binding domain of the mRNA export factor tap”. X-ray diffraction, 8 pockets (best druggability 0.83). MolNFT v1 #6988 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 1FT8
- Type
- protein
- Length
- 857 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tip associating protein
- UniProt
- Q9UBU9
- Pockets
- 8 · best druggability 0.83
Structure
x-ray diffraction · 5 distinct chains · 36% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tip associating protein | protein | 242 | 34% helix, 19% strand | Q9UBU9 |
| B | Tip associating protein | protein | 165 | 39% helix, 11% strand | Q9UBU9 |
| C | Tip associating protein | protein | 244 | 34% helix, 18% strand | Q9UBU9 |
| D | Tip associating protein | protein | 162 | 39% helix, 11% strand | Q9UBU9 |
| E | Tip associating protein | protein | 44 | 43% helix, 16% strand | Q9UBU9 |
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1032 | 0.83 | 0.84 | 79 | empty |
| 2 | 1004 | 0.81 | 0.82 | 78 | empty |
| 3 | 76 | 0.72 | 0.96 | 20 | empty |
| 4 | 90 | 0.70 | 0.94 | 19 | empty |
| 5 | 456 | 0.67 | 0.79 | 63 | empty |
Interfaces
7 interfaces between chains.
- B–C · 1036 Ų buried · 5 hydrogen bonds · protein-protein
- A–D · 965 Ų buried · 3 hydrogen bonds · protein-protein
- C–D · 724 Ų buried · 18 hydrogen bonds · protein-protein
- A–B · 692 Ų buried · 8 hydrogen bonds · protein-protein
- B–D · 582 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 1FT8 · Crystal structure of the RNA-binding domain of the mRNA export factor tap · the same entry in another collection · chain E against E, TM-score 1.00
- Q9UBU9 · AlphaFold monomer V2.0 prediction for nuclear RNA export factor 1 (Q9UBU9) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UBU9
- Elsewhere: RCSB PDB 1FT8 · PDBe 1FT8 · UniProt Q9UBU9
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