MolNFT v1 · #6970 · protein

X-ray crystal structure of cobalt-bound F93S/F95L/W97M carbonic anhydrase (caii) variant

1FSQ · Carbonic anhydrase II: “X-ray crystal structure of cobalt-bound F93S/F95L/W97M carbonic anhydrase (caii) variant”. X-ray diffraction, 1 ligand (CO), 4 pockets (best druggability 0.55). MolNFT v1 #6970 on GenesisL1: 3D structure…

PDB: 1FSQ
Type: protein
Length: 516 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Carbonic anhydrase II
EC: 4.2.1.1
UniProt: P00918
Ligands: CO
Pockets: 4 · best druggability 0.55

Structure

x-ray diffraction · 1 distinct chain · 14% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Carbonic anhydrase II (EC 4.2.1.1)	protein	258	14% helix, 31% strand	P00918

Ligands and binding sites

CO · Cobalt (II) ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	151	0.55	0.81	27	empty
2	165	0.53	0.79	28	empty
3	83	0.32	0.74	16	empty
4	69	0.31	0.74	16	empty

Compared structures

1FSQ · X-ray crystal structure of cobalt-bound F93S/F95L/W97M carbonic anhydrase (caii) variant · the same entry in another collection · chain A against A, TM-score 1.00
P00918 · AlphaFold monomer V2.0 prediction for carbonic anhydrase 2 (P00918) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00918
Elsewhere: RCSB PDB 1FSQ · PDBe 1FSQ · UniProt P00918

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.