MolNFT v1 · #69693 · protein
Crystal structure of fibroblast growth factor receptor 1 kinase domain
3KY2 · Basic fibroblast growth factor receptor 1: “Crystal structure of fibroblast growth factor receptor 1 kinase domain”. X-ray diffraction, 1 ligand (SO4), 6 pockets (best druggability 0.75). MolNFT v1 #69693 on GenesisL1: 3D structure…
- PDB
- 3KY2
- Type
- protein
- Length
- 587 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Basic fibroblast growth factor receptor 1
- EC
- 2.7.10.1
- UniProt
- P11362
- Ligands
- SO4
- Pockets
- 6 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Basic fibroblast growth factor receptor 1 (EC 2.7.10.1) | protein | 307 | 36% helix, 14% strand | P11362 |
| B | Basic fibroblast growth factor receptor 1 (EC 2.7.10.1) | protein | 280 | 40% helix, 16% strand | P11362 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 904 | 0.75 | 0.78 | 58 | SO4 |
| 2 | 482 | 0.68 | 0.79 | 57 | empty |
| 3 | 534 | 0.67 | 0.77 | 59 | SO4 |
| 4 | 52 | 0.33 | 0.78 | 18 | empty |
| 5 | 51 | 0.26 | 0.73 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 395 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3KY2 · Crystal structure of Fibroblast Growth Factor Receptor 1 kinase domain · the same entry in another collection · chain A against A, TM-score 1.00
- P11362 · AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor 1 (P11362) · a predicted model of the same protein · chain B against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11362
- Elsewhere: RCSB PDB 3KY2 · PDBe 3KY2 · UniProt P11362
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.