MolNFT v1 · #69580 · protein

Crystal structure of the DLC1 rhogap domain

3KUQ · Rho GTPase-activating protein 7: “Crystal structure of the DLC1 rhogap domain”. X-ray diffraction, 1 ligand (UNX), 2 pockets (best druggability 0.39). MolNFT v1 #69580 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3KUQ
Type: protein
Length: 192 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Rho GTPase-activating protein 7
UniProt: Q96QB1
Ligands: UNX
Pockets: 2 · best druggability 0.39

Structure

x-ray diffraction · 1 distinct chain · 65% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Rho GTPase-activating protein 7	protein	192	65% helix, 1% strand	Q96QB1

Ligands and binding sites

UNX · Unknown atom or ion · ion · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	127	0.39	0.74	13	empty
2	51	0.33	0.78	15	UNX

Compared structures

3KUQ · Crystal structure of the DLC1 RhoGAP domain · the same entry in another collection · chain A against A, TM-score 1.00
Q96QB1 · AlphaFold monomer V2.0 prediction for rho GTPase-activating protein 7 (Q96QB1) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96QB1
Elsewhere: RCSB PDB 3KUQ · PDBe 3KUQ · UniProt Q96QB1

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