MolNFT v1 · #69163 · protein

Crystal structures of urokinase-type plasminogen activator in complex with 4-(aminomethyl) benzoic acid and 4-(aminomethyl-phenyl)-methanol

3KHV: “Crystal structures of urokinase-type plasminogen activator in complex with 4-(aminomethyl) benzoic acid and…”. X-ray diffraction, 2 ligands (4AL, SO4), 1 pocket (best druggability 0.39). MolNFT v1 #69163 on GenesisL1: 3D structure…

PDB: 3KHV
Type: protein
Length: 239 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Urokinase-type plasminogen activator
EC: 3.4.21.73
UniProt: P00749
Ligands: 4AL, SO4
Pockets: 1 · best druggability 0.39

Structure

x-ray diffraction · 1 distinct chain · 10% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Urokinase-type plasminogen activator (EC 3.4.21.73)	protein	239	10% helix, 38% strand	P00749

Ligands and binding sites

4AL · [4-(aminomethyl)phenyl]methanol · ligand · chains A
SO4 · Sulfate ion · ion · chains A
PGE · Triethylene glycol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	101	0.39	0.76	33	4AL, SO4

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

3KHV · Crystal Structures of Urokinase-type Plasminogen Activator in Complex with… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00749
Elsewhere: RCSB PDB 3KHV · PDBe 3KHV · UniProt P00749

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.