MolNFT v1 · #69125 · protein
Crystal structure of the human leukocyte-associated ig-like receptor-1 (lair-1)
3KGR · Leukocyte-associated immunoglobulin-like receptor 1: “Crystal structure of the human leukocyte-associated ig-like receptor-1 (lair-1)”. X-ray diffraction, 1 ligand (GLY), 2 pockets (best druggability 0.59). MolNFT v1 #69125 on…
- PDB
- 3KGR
- Type
- protein
- Length
- 295 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Leukocyte-associated immunoglobulin-like receptor 1
- UniProt
- Q6GTX8
- Ligands
- GLY
- Pockets
- 2 · best druggability 0.59
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 55% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Leukocyte-associated immunoglobulin-like receptor 1 | protein | 99 | 6% helix, 56% strand | Q6GTX8 |
| B | Leukocyte-associated immunoglobulin-like receptor 1 | protein | 97 | 3% helix, 55% strand | Q6GTX8 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 471 | 0.59 | 0.74 | 53 | empty |
| 2 | 215 | 0.50 | 0.75 | 24 | empty |
Interfaces
2 interfaces between chains.
- A–B · 480 Ų buried · 13 hydrogen bonds · protein-protein
- A–C · 290 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 3KGR · Crystal structure of the human leukocyte-associated Ig-like receptor-1 (LAIR-1) · the same entry in another collection · chain A against A, TM-score 1.00
- Q6GTX8 · AlphaFold monomer V2.0 prediction for leukocyte-associated immunoglobulin-like receptor 1… · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6GTX8
- Elsewhere: RCSB PDB 3KGR · PDBe 3KGR · UniProt Q6GTX8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.