MolNFT v1 · #68619 · protein

Crystal structure of fancl

3K1L: “Crystal structure of fancl”. X-ray diffraction, 3 ligands (GLC, AU, ZN), 10 pockets (best druggability 0.78). MolNFT v1 #68619 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3K1L
Type: protein
Length: 740 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fancl
EC: 6.3.2.19
UniProt: Q8T913
Ligands: GLC, AU, ZN
Pockets: 10 · best druggability 0.78

Structure

x-ray diffraction · 2 distinct chains · 30% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Fancl (EC 6.3.2.19)	protein	364	30% helix, 24% strand	Q8T913
A	Fancl (EC 6.3.2.19)	protein	376	31% helix, 23% strand	Q8T913

Ligands and binding sites

GLC · alpha-D-glucopyranose · sugar · 4 copies · chains B, A
AU · Gold ion · metal · 13 copies · chains B, A
ZN · Zinc ion · metal · 4 copies · chains B, A
CIT · Citric acid · additive · 3 copies · chains B, A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

10 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1147	0.78	0.80	114	empty
2	1059	0.73	0.76	98	empty
3	99	0.47	0.80	25	empty
4	96	0.45	0.80	18	empty
5	116	0.45	0.78	22	empty

Interfaces

1 interface between chains.

B–A · 2652 Å² buried · 23 hydrogen bonds · protein-protein

Compared structures

3K1L · Crystal Structure of FANCL · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8T913
Elsewhere: RCSB PDB 3K1L · PDBe 3K1L · UniProt Q8T913

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