MolNFT v1 · #68312 · protein

Solvent-stable cholesterol oxidase

3JS8: “Solvent-stable cholesterol oxidase”. X-ray diffraction, 3 ligands (FAD, GLC, FRU), 4 pockets (best druggability 0.89). MolNFT v1 #68312 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3JS8
Type: protein
Length: 538 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cholesterol oxidase
EC: 1.1.3.6
UniProt: B5MGF8
Ligands: FAD, GLC, FRU
Pockets: 4 · best druggability 0.89

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cholesterol oxidase (EC 1.1.3.6)	protein	538	31% helix, 23% strand	B5MGF8

Ligands and binding sites

FAD · Flavin-adenine dinucleotide · ligand · chains A
GLC · alpha-D-glucopyranose · sugar · chains A
FRU · beta-D-fructofuranose · sugar · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	624	0.89	0.94	74	FAD
2	91	0.37	0.76	20	empty
3	64	0.33	0.76	20	empty
4	57	0.29	0.75	16	empty

Modifications

Observed in the structure: 1 cofactor (flavinylation).

Compared structures

3JS8 · Solvent-stable cholesterol oxidase · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B5MGF8
Elsewhere: RCSB PDB 3JS8 · PDBe 3JS8 · UniProt B5MGF8

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