MolNFT v1 · #68191 · protein
Cryo-EM reconstruction of F-actin
3JBJ · Actin, alpha skeletal muscle: “Cryo-EM reconstruction of F-actin”. Electron microscopy, 2 ligands (ADP, MG), 8 pockets (best druggability 0.77). MolNFT v1 #68191 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3JBJ
- Type
- protein
- Length
- 734 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Actin, alpha skeletal muscle
- UniProt
- P68135
- Ligands
- ADP, MG
- Pockets
- 8 · best druggability 0.77
Structure
electron microscopy · 1 distinct chain · 39% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Actin, alpha skeletal muscle | protein | 367 | 39% helix, 20% strand | P68135 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 135 | 0.77 | 0.95 | 33 | empty |
| 2 | 104 | 0.75 | 0.96 | 28 | empty |
| 3 | 216 | 0.68 | 0.85 | 38 | ADP |
| 4 | 158 | 0.64 | 0.86 | 32 | ADP |
| 5 | 255 | 0.55 | 0.76 | 39 | empty |
Interfaces
1 interface between chains.
- A–B · 1188 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P68135
- Elsewhere: RCSB PDB 3JBJ · PDBe 3JBJ · UniProt P68135
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