MolNFT v1 · #68053 · protein
Pseudo-atomic model of the AKAP18-PKA complex in a bent conformation derived from electron microscopy
3J4Q · A-kinase anchor protein 18: “Pseudo-atomic model of the AKAP18-PKA complex in a bent conformation derived from electron microscopy”. Electron microscopy, 20 pockets (best druggability 0.73). MolNFT v1 #68053 on GenesisL1: 3D…
- PDB
- 3J4Q
- Type
- protein
- Length
- 1,644 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- A-kinase anchor protein 18; Camp-dependent protein kinase type II-alpha regulatory…
- EC
- 2.7.11.11
- UniProt
- Q8K1M3, P05132
- Pockets
- 20 · best druggability 0.73
Structure
electron microscopy · 3 distinct chains · 36% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | A-kinase anchor protein 18 | protein | 230 | 39% helix, 24% strand | — |
| B, C | Camp-dependent protein kinase type II-alpha regulatory subunit | protein | 382 | 33% helix, 25% strand | Q8K1M3 |
| D, E | Camp-dependent protein kinase catalytic subunit alpha (EC 2.7.11.11) | protein | 325 | 37% helix, 13% strand | P05132 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1011 | 0.73 | 0.76 | 69 | empty |
| 2 | 749 | 0.69 | 0.76 | 65 | empty |
| 3 | 338 | 0.62 | 0.78 | 33 | empty |
| 4 | 288 | 0.61 | 0.79 | 39 | empty |
| 5 | 305 | 0.59 | 0.78 | 42 | empty |
Interfaces
5 interfaces between chains.
- C–E · 1914 Ų buried · 36 hydrogen bonds · protein-protein
- B–D · 1777 Ų buried · 29 hydrogen bonds · protein-protein
- B–C · 833 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 314 Ų buried · 0 hydrogen bonds · protein-protein
- A–B · 310 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 3J4Q · Pseudo-atomic model of the AKAP18-PKA complex in a bent conformation derived from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8K1M3
- Every structure of UniProt P05132
- Elsewhere: RCSB PDB 3J4Q · PDBe 3J4Q · UniProt Q8K1M3 · UniProt P05132
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