MolNFT v1 · #68008 · protein
Structure of late pre-60S ribosomal subunits with nuclear export factor ARX1 bound at the peptide exit tunnel
3J2I · Eukaryotic translation initiation factor 6: “Structure of late pre-60S ribosomal subunits with nuclear export factor ARX1 bound at the peptide exit tunnel”. Electron microscopy, 7 pockets (best druggability 0.81). MolNFT v1 #68008…
- PDB
- 3J2I
- Type
- protein
- Length
- 578 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 6; Proliferation-associated protein 2G4
- UniProt
- Q12522, Q9UQ80
- Pockets
- 7 · best druggability 0.81
Structure
electron microscopy · 2 distinct chains · 33% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Eukaryotic translation initiation factor 6 | protein | 224 | 32% helix, 28% strand | Q12522 |
| A | Proliferation-associated protein 2G4 | protein | 354 | 34% helix, 25% strand | Q9UQ80 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 130 | 0.81 | 0.99 | 30 | empty |
| 2 | 253 | 0.64 | 0.82 | 26 | empty |
| 3 | 144 | 0.49 | 0.78 | 26 | empty |
| 4 | 66 | 0.36 | 0.77 | 13 | empty |
| 5 | 75 | 0.34 | 0.75 | 20 | empty |
Compared structures
- 3J2I · Structure of late pre-60S ribosomal subunits with nuclear export factor Arx1 bound at the… · the same entry in another collection · chain B against B, TM-score 1.00
- Q9UQ80 · AlphaFold monomer V2.0 prediction for proliferation-associated protein 2G4 (Q9UQ80) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q12522 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 6 (Q12522) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12522
- Every structure of UniProt Q9UQ80
- Elsewhere: RCSB PDB 3J2I · PDBe 3J2I · UniProt Q12522 · UniProt Q9UQ80
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