UniProt Q12522
Eukaryotic translation initiation factor 6 (Q12522)
Eukaryotic translation initiation factor 6 (UniProt Q12522): 44 experimental structures on GenesisL1, 10 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q12522
- Protein
- Eukaryotic translation initiation factor 6
- Experimental structures
- 44
- Predicted models
- 0
- Pockets
- 10 · 9 records with a druggable one
Structures
44 records of Q12522 in the MolNFT archive: 44 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1G62 | Crystal structure of S.CEREVISIAE EIF6 | x-ray diffraction | A | — | — |
| 1G62 | Crystal structure of S.CEREVISIAE EIF6 | x-ray diffraction | A | — | — |
| 2X7N | Mechanism of eIF6s anti-association activity | electron microscopy | B | — | — |
| 2X7N | Mechanism of EIF6S anti-association activity | electron microscopy | B | — | — |
| 3J2I | Structure of late pre-60S ribosomal subunits with nuclear export factor Arx1 bound at the peptide… | electron microscopy | B | — | — |
| 3J2I | Structure of late pre-60S ribosomal subunits with nuclear export factor ARX1 bound at the peptide… | electron microscopy | B | — | — |
| 3JCT | Cryo-em structure of eukaryotic pre-60S ribosomal subunits | electron microscopy | y | — | — |
| 4V7F | Arx1 pre-60S particle. | electron microscopy | m | — | — |
| 4V7F | ARX1 pre-60S particle. | electron microscopy | m | — | — |
| 5H4P | Structural snapshot of cytoplasmic pre-60S ribosomal particles bound with Nmd3, Lsg1, Tif6 and Reh1 | electron microscopy | y | — | — |
| 5JCS | Cryo-EM structure of the RIX1-REA1 pre-60S particle | electron microscopy | m | — | — |
| 5T62 | Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome… | electron microscopy | X | — | — |
| 5Z3G | Cryo-EM structure of a nucleolar pre-60S ribosome (RPF1-tap) | electron microscopy | N | — | — |
| 6C0F | Yeast nucleolar pre-60S ribosomal subunit (state 2) | electron microscopy | y | — | — |
| 6C0F | Yeast nucleolar pre-60S ribosomal subunit (state 2) | electron microscopy | y | — | — |
| 6ELZ | State E (TAP-Flag-Ytm1 E80A) - Visualizing the assembly pathway of nucleolar pre-60S ribosomes | electron microscopy | y | — | — |
| 6EM4 | State B architectural model (NSA1-tap flag-YTM1) - visualizing the assembly pathway of nucleolar… | electron microscopy | y | — | — |
| 6EM5 | State D architectural model (Nsa1-TAP Flag-Ytm1) - Visualizing the assembly pathway of nucleolar… | electron microscopy | y | — | 1 (best 0.73) |
| 6EM5 | State D architectural model (NSA1-tap flag-YTM1) - visualizing the assembly pathway of nucleolar… | electron microscopy | y | — | — |
| 6M62 | Cryo-Em structure of eukaryotic pre-60S ribosome subunit from Saccharomyces cerevisiae rpf2 delta… | electron microscopy | y | — | — |
| 6N8J | Cryo-EM structure of late nuclear (LN) pre-60S ribosomal subunit | electron microscopy | y | — | 1 (best 0.88) |
| 6N8K | Cryo-EM structure of early cytoplasmic-immediate (ECI) pre-60S ribosomal subunit | electron microscopy | y | — | — |
| 6N8L | Cryo-EM structure of early cytoplasmic-late (ECL) pre-60S ribosomal subunit | electron microscopy | y | — | — |
| 6N8M | Cryo-EM structure of pre-Lsg1 (PL) pre-60S ribosomal subunit | electron microscopy | X | — | — |
| 6N8N | Cryo-EM structure of Lsg1-engaged (LE) pre-60S ribosomal subunit | electron microscopy | X | — | — |
| 6N8O | Cryo-EM structure of Rpl10-inserted (RI) pre-60S ribosomal subunit | electron microscopy | X | — | — |
| 6QIK | Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles | electron microscopy | n | — | — |
| 6R84 | Yeast Vms1 (Q295L)-60S ribosomal subunit complex (pre-state with Arb1) | electron microscopy | X | — | — |
| 6RI5 | Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles | electron microscopy | n | — | — |
| 6S05 | Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles | electron microscopy | n | — | — |
| 7NAC | State E2 nucleolar 60S ribosomal biogenesis intermediate - Composite model | electron microscopy | y | — | — |
| 7NAF | State E2 nucleolar 60S ribosomal biogenesis intermediate - Spb1-MTD local model | electron microscopy | y | — | — |
| 7OH3 | Nog1-TAP associated immature ribosomal particle population B from S. cerevisiae | electron microscopy | y | — | 1 (best 0.84) |
| 7OHP | Nog1-TAP associated immature ribosomal particles from S. cerevisiae after rpL25 expression shut… | electron microscopy | y | — | 1 (best 0.84) |
| 7OHR | Nog1-TAP associated immature ribosomal particle population E from S. cerevisiae | electron microscopy | y | — | 1 (best 0.85) |
| 7OHS | Nog1-TAP associated immature ribosomal particle population F from S. cerevisiae | electron microscopy | y | — | — |
| 7UG6 | Cryo-EM structure of pre-60S ribosomal subunit, unmethylated G2922 | electron microscopy | y | — | — |
| 7UOO | Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state | electron microscopy | y | — | 1 (best 0.90) |
| 7ZS5 | Structure of 60S ribosomal subunit from S. cerevisiae with eIF6 and tRNA | electron microscopy | A | — | — |
| 8AGW | Yeast RQC complex in state D | electron microscopy | g | — | 1 (best 0.88) |
| 8AGZ | Yeast RQC complex in state with the RING domain of Ltn1 in the OUT position | electron microscopy | g | — | — |
| 8V83 | 60S ribosome biogenesis intermediate (Dbp10 pre-catalytic structure - Overall map) | electron microscopy | y | — | 2 (best 0.86) |
| 8V84 | 60S ribosome biogenesis intermediate (Dbp10 catalytic structure - Overall map) | electron microscopy | y | — | 1 (best 0.87) |
| Q12522 | AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 6 (Q12522) | — | — | — |
Elsewhere
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