MolNFT v1 · #67819 · protein
Structures of spop-substrate complexes: insights into molecular architectures of btb-CUL3 ubiquitin ligases: spopmath-CISBC2
3IVQ · Speckle-type poz protein: “Structures of spop-substrate complexes: insights into molecular architectures of btb-CUL3 ubiquitin ligases…”. X-ray diffraction, 1 pocket (best druggability 0.67). MolNFT v1 #67819 on GenesisL1: 3D…
- PDB
- 3IVQ
- Type
- protein
- Length
- 293 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Speckle-type poz protein; CISBC2
- UniProt
- O43791
- Pockets
- 1 · best druggability 0.67
Structure
x-ray diffraction · 4 distinct chains · 12% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Speckle-type poz protein | protein | 140 | 14% helix, 50% strand | O43791 |
| C | CISBC2 | protein | 8 | 0% helix, 13% strand | — |
| B | Speckle-type poz protein | protein | 138 | 12% helix, 54% strand | O43791 |
| D | CISBC2 | protein | 7 | 0% helix, 14% strand | — |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 258 | 0.67 | 0.83 | 29 | empty |
Interfaces
3 interfaces between chains.
- B–D · 448 Ų buried · 8 hydrogen bonds · protein-protein
- A–C · 440 Ų buried · 12 hydrogen bonds · protein-protein
- A–B · 310 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 3IVQ · Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3… · the same entry in another collection · chain A against A, TM-score 1.00
- O43791 · AlphaFold monomer V2.0 prediction for speckle-type poz protein (O43791) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O43791
- Elsewhere: RCSB PDB 3IVQ · PDBe 3IVQ · UniProt O43791
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