MolNFT v1 · #67810 · protein

Crystal structure of the talin head ferm domain

3IVF · Talin-1: “Crystal structure of the talin head ferm domain”. X-ray diffraction, 2 pockets (best druggability 0.41). MolNFT v1 #67810 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3IVF
Type: protein
Length: 358 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Talin-1
UniProt: P26039
Pockets: 2 · best druggability 0.41

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Talin-1	protein	358	34% helix, 28% strand	P26039

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	138	0.41	0.74	26	empty
2	55	0.28	0.74	17	empty

Compared structures

3IVF · Crystal structure of the talin head FERM domain · the same entry in another collection · chain A against A, TM-score 1.00
P26039 · AlphaFold monomer V2.0 prediction for talin-1 (P26039) · a predicted model of the same protein · chain A against A, TM-score 0.54

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P26039
Elsewhere: RCSB PDB 3IVF · PDBe 3IVF · UniProt P26039

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