MolNFT v1 · #67546 · protein

Unraveling the structure of interleukin-2: reply

3INK: “Unraveling the structure of interleukin-2: reply”. X-ray diffraction, 2 pockets (best druggability 0.55). MolNFT v1 #67546 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3INK
Type: protein
Length: 242 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Interleukin-2
UniProt: P60568
Pockets: 2 · best druggability 0.55

Structure

x-ray diffraction · 1 distinct chain · 63% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C, D	Interleukin-2	protein	121	63% helix, 8% strand	P60568

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	183	0.55	0.80	25	empty
2	58	0.29	0.75	12	empty

Interfaces

1 interface between chains.

C–D · 507 Å² buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

3INK · Unraveling the structure of interleukin-2: reply · the same entry in another collection · chain C against C, TM-score 1.00
P60568 · AlphaFold monomer V2.0 prediction for interleukin-2 (P60568) · a predicted model of the same protein · chain C against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P60568
Elsewhere: RCSB PDB 3INK · PDBe 3INK · UniProt P60568

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.