MolNFT v1 · #67543 · protein

Crystal structure of homoserine dehydrogenase (NP_394635.1) from thermoplasma acidophilum at 1.95 a resolution

3ING: “Crystal structure of homoserine dehydrogenase (NP_394635.1) from thermoplasma acidophilum at 1.95 a resolution”. X-ray diffraction, 2 ligands (NDP, NA), 2 pockets (best druggability 0.73). MolNFT v1 #67543 on GenesisL1: 3D…

PDB: 3ING
Type: protein
Length: 319 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Homoserine dehydrogenase
UniProt: Q9HIZ7
Ligands: NDP, NA
Pockets: 2 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Homoserine dehydrogenase	protein	319	42% helix, 22% strand	Q9HIZ7

Ligands and binding sites

NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · ligand · chains A
NA · Sodium ion · metal · chains A
EDO · 1,2-ethanediol · additive · 6 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	261	0.73	0.88	44	NDP
2	75	0.32	0.74	16	EDO

Modifications

Observed in the structure: 8 modified (engineered).

Compared structures

3ING · Crystal structure of Homoserine dehydrogenase (NP_394635.1) from THERMOPLASMA ACIDOPHILUM… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9HIZ7
Elsewhere: RCSB PDB 3ING · PDBe 3ING · UniProt Q9HIZ7

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